ScrapieScrapie is a Transmissible Spongiform Encephalopathy (TSE) that affects sheep and goats, which was first described more than 200 years ago and to which attention has only been paid very recently, after the health emergency that arose after bovine BSE due to possible transmission to humans. of these particular types of diseases after supposedly eating foods of animal origin containing the prion, the protein that would lead to the disease. In sheep it has been shown that a PRNP locus found on chromosome 13 (Oar13) presents high genetic variability within the European sheep flock and the presence of some variants can confer greater or lesser resistance to the disease. Of all these polymorphisms, those that affect codons 136, 154 and 171 are those that have been described as most related to the degree of suffering from the disease. These mutations give rise to the 5 haplotypes called, respectively, ARQ, VRQ, AHQ, ARR and ARH. With these data, it has been established that, in general, ARR/ARR animals are the most resistant and VRQ/VRQ are the most sensitive to suffering from the disease.
|Hair, Blood, Tissues
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